TITIN is a “Titan” sized protein found as the flexible strength of muscles. This protein can remarkably maintain strength while stretching and folding into stacks of sheet-like material.
Titin is the longest Amino Acid protein chain found In the human body and has the strongest protein bond found (so far) in nature! This giant protein organizes the structure of muscles and gives them elasticity. It is the largest protein chain in your body, with more than 38,000 amino acids! This “titanic” protein acts like a big rubber band in our muscles.-1
“The human titin gene comprises 363 exons predicted to code for up to 38,138 residues, or a protein size of 4.2 MDa. Thus, titin is the largest protein in the human body.” National Library of Medicine -1
Imagine the complexity required for protein synthesis for such a monster protein! The likelihood of this monster forming by blind gradual mutations is beyond absurd. It is outside even super cosmic probabilities!
Titin is a challenge to evolution today. However, this amino acid sequence has existed in various animal families (not just humans) such as the Zebrafish. This “prehistoric” fish is found in fossils dating back to the Paleozoic more than 359 million years ago! Less than 200 million years after the Cambrian explosion of the first multi-cellular life! Evolution was churning out protein chains of over 38,000 amino acids in length over 350 million years ago. Wow!
1-Krüger M, Linke WA. The giant protein titin: a regulatory node that integrates myocyte signaling pathways. J Biol Chem. 2011 Mar 25;286(12):9905-12. doi: 10.1074/jbc.R110.173260. Epub 2011 Jan 21. PMID: 21257761; PMCID: PMC3060543; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060543/#:~:text=The%20human%20titin%20gene%20comprises,protein%20in%20the%20human%20body.