Biological • Evolutionary Puzzles • Intelligent Design

PROTEIN TITIN: OVER 38,000 AMINO ACIDS LONG!

Titin is a highly specialized protein that provides flexibility to muscles in many animals. When Titin is written out it is the longest English word comprised of 189,819 letters. The word takes three and a half hours to pronounce! It consists of more than 38,000 amino acids in its protein chain—each amino acid letter precisely placed in sequence by stunning DNA informational blueprints. Mathematical likelihoods of an amino acid chain of only 100 randomly and spontaneously forming requires a near miracle. When such math odds are applied to Titin calculators melt down.

TITIN is a “Titan” sized protein found as the flexible strength of muscles. This protein can remarkably maintain strength while stretching and folding into stacks of sheet-like material.

Titin is the longest Amino Acid protein chain found In the human body and has the strongest protein bond found (so far) in nature!  This giant protein organizes the structure of muscles and gives them elasticity.  It is the largest protein chain in your body, with more than 38,000 amino acids! This “titanic” protein acts like a big rubber band in our muscles.-1

“The human titin gene comprises 363 exons predicted to code for up to 38,138 residues, or a protein size of 4.2 MDa. Thus, titin is the largest protein in the human body.” National Library of Medicine -1

Imagine the complexity required for protein synthesis for such a monster protein! The likelihood of this monster forming by blind gradual mutations is beyond absurd. It is outside even super cosmic probabilities!

Titin is a challenge to evolution today. However, this amino acid sequence has existed in various animal families (not just humans) such as the Zebrafish. This “prehistoric” fish is found in fossils dating back to the Paleozoic more than 359 million years ago! Less than 200 million years after the Cambrian explosion of the first multi-cellular life! Evolution was churning out protein chains of over 38,000 amino acids in length over 350 million years ago. Wow!

Titin is the longest word in English, with 189,819 letters.  It would take you 3.5 hours to pronounce correctly.

“Methionylthreonylthreonylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylglutaminylleucyllysylglutamylarginyllysylglutamylglycylalanylphenylalanylvalyl…”

Titin proteins are elastic and connect the myosin filaments to the Z line for muscle relaxing and flexing.
This diagram are the Titin proteins in a relaxed state.

Sources:

1-Krüger M, Linke WA. The giant protein titin: a regulatory node that integrates myocyte signaling pathways. J Biol Chem. 2011 Mar 25;286(12):9905-12. doi: 10.1074/jbc.R110.173260. Epub 2011 Jan 21. PMID: 21257761; PMCID: PMC3060543; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060543/#:~:text=The%20human%20titin%20gene%20comprises,protein%20in%20the%20human%20body.

images: http://pdb101.rcsb.org/motm/185

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